Charging through an enemy, or group, to force a flank situation between your companion and you is helpful. But, sometimes an enemy can get hit you while you're charging, resulting in a flanking bonus for them (more damage on you).
Charging through enemies is also a good way to attack the protected healers quicker.
Charge also allows escaping a gas cloud quicker, or other damage-per-second area.
Downside of Charge is that if your facing the wrong way, easy to do in a group fight, you end up not hitting anyone.